Publication: Pharmacokinetics of mefloquine, when given alone and in combination with artemether, in patients with uncomplicated falciparum malaria
Issued Date
1995-12-01
Resource Type
ISSN
14728206
07673981
07673981
Other identifier(s)
2-s2.0-0029563974
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Mahidol University
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SCOPUS
Bibliographic Citation
Fundamental and Clinical Pharmacology. Vol.9, No.6 (1995), 576-582
Suggested Citation
K. Na-Bangchang, J. Karbwang, P. Molunto, V. Banmairuroi, A. Thanavibul Pharmacokinetics of mefloquine, when given alone and in combination with artemether, in patients with uncomplicated falciparum malaria. Fundamental and Clinical Pharmacology. Vol.9, No.6 (1995), 576-582. doi:10.1016/0767-3981(96)89489-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17358
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Title
Pharmacokinetics of mefloquine, when given alone and in combination with artemether, in patients with uncomplicated falciparum malaria
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Abstract
The pharmacokinetics of mefloquine at a single oral dose of 750 mg, when given alone or 24 hours after a single oral dose of artemether (300 mg) was investigated in 27 Thai patients with acute uncomplicated falciparum malaria (17 with mefloquine alone, 10 with the combination). The oral bioavailabiiity of mefloquine was significantly decreased when administered 24 hours after an oral dose of artemether. This was evident by the significantly lower values of Cmax, AUC[0-24 h], AUC[0-48 h], AUC[0-72 h], as well as total AUC[Cmax: 1,290 (827-2,619) vs 1,820 (1,283-2,531) ng·ml-1; AUC[0-24 h]: 0.99 (0.64-1.41) vs 1.33 (1.07-1.95) μg·day·ml-1; AUC[0-48 h]: 1.78(1.23-2.58) vs 2.67 (2.09-3.84) μg·day·ml-1; AUC[0-72 h]: 2.74 (1.63-3.6) vs 4.54 (2.88-5.38) μg·day·ml-1; AUC: 11.11 (6-20.96) vs 15.29 (9.3-36.71) μg·day·ml-1]. Tmax was also delayed with the combination regimen [14 (5-24) vs 6 (4-16) h]. Terminal elimination half-lives were comparable [t1/2z: 11.1 (6.8-14.3) vs 13.4 (10.5-19.1) h]. © 1995 Elsevier, Paris.