Antimicrobial Agents and Chemotherapy. Vol.39, No.10 (1995), 2356-2358
Suggested Citation
L. Walsh, M. D. Smith, V. Wuthiekanun, N. J. White Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment. Antimicrobial Agents and Chemotherapy. Vol.39, No.10 (1995), 2356-2358. doi:10.1128/AAC.39.10.2356 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17452
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Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment
The postantibiotic effects (PAEs) of 16 antibiotics or antibiotic combinations currently used against Burkholderia (Pseudomonas) pseudomallei were determined. The β-lactams had zero PAEs, while the carbapenems and ciprofloxacin induced median PAEs of 1 and 5 h, respectively. These results emphasize the need to maintain antibiotic levels above inhibitory concentrations in blood throughout the dosing interval in cases of severe melioidosis.
