Publication:
In-vitro activity of carbapenem antibiotics against β-lactam susceptible and resistant strains of Burkholderia pseudomallei

1

Issued Date

1996-04-29

Resource Type

Article

ISSN

03057453

DOI

10.1093/jac/37.3.611

Other identifier(s)

2-s2.0-0029997403

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Antimicrobial Chemotherapy. Vol.37, No.3 (1996), 611-615

Suggested Citation

M. D. Smith, V. Wuthiekanun, A. L. Walsh, N. J. White In-vitro activity of carbapenem antibiotics against β-lactam susceptible and resistant strains of Burkholderia pseudomallei. Journal of Antimicrobial Chemotherapy. Vol.37, No.3 (1996), 611-615. doi:10.1093/jac/37.3.611 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17744

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Title

In-vitro activity of carbapenem antibiotics against β-lactam susceptible and resistant strains of Burkholderia pseudomallei

Author(s)

M. D. Smith
 V. Wuthiekanun
 A. L. Walsh
 N. J. White

Other Contributor(s)

Mahidol University
 Nuffield Department of Clinical Medicine

Abstract

Four carbapenem antibiotics were tested for their in-vitro activities (MICs, MBCs and time-kill studies) against Burkholderia pseudomallei. The carbapenems were all more active than either ceftazidime or co-amoxiclav against strains of B. pseudomallei with a normal susceptibility pattern. Biapenem was the most active antibiotic tested. All four carbapenems retained bactericidal activity against 24 strains of B. pseudomallei with reduced susceptibility to ceftazidime and/or co-amoxiclav.

Keyword(s)

Medicine
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/17744

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Scopus 1991-2000