Publication: Neuropharmacological actions of Pluchea indica Less root extract in socially isolated mice
Issued Date
1996-01-01
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09186158
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2-s2.0-0029922182
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Mahidol University
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SCOPUS
Bibliographic Citation
Biological and Pharmaceutical Bulletin. Vol.19, No.3 (1996), 379-383
Suggested Citation
Suchitra Thongpraditchote, Kinzo Matsumoto, Rungravi Temsiririrkkul, Michihisa Tohda, Yukihisa Murakami, Hiroshi Watanabe Neuropharmacological actions of Pluchea indica Less root extract in socially isolated mice. Biological and Pharmaceutical Bulletin. Vol.19, No.3 (1996), 379-383. doi:10.1248/bpb.19.379 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17837
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Title
Neuropharmacological actions of Pluchea indica Less root extract in socially isolated mice
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Abstract
The effects of Pluchea indica Less root extract (PI-E) on locomotor activity and pentobarbital-induced sleep, social isolation-induced aggressive behavior, motor coordination in the rotarod test, pentylenetetrazole-induced convulsion and nociceptive responses in the tail-pinch test were examined in mice. Socially isolated mice showed higher locomotor activity and shorter duration of pentobarbital sleep than group-housed mice. PI-E (50-100 mg/kg, p.o.) significantly decreased locomotor activity and prolonged pentobarbital sleep in a dose-dependent manner in isolated mice but not in group-housed mice. At a large dose (400 mg/kg, p.o.), PI-E not only decreased locomotor activity but also prolonged pentobarbital sleep in group-housed mice. The reference drug diazepam, at 0.5 mg/kg, also suppressed the locomotor activity in isolated mice but not in group-housed mice. Moreover, diazepam, at 0.1 and 0.5 mg/kg, significantly prolonged pentobarbital sleep in both isolated mice and group-housed mice. The effects of PI-E and diazepam on pentobarbital sleep in isolated mice were significantly attenuated by flumazenil (1 mg/kg, i.v.). PI-E (50-100 mg/kg), as well as diazepam (0.5-5 mg/kg, p.o.), dose- dependently suppressed social isolation-induced aggressive behavior, but it had no effect on pentylenetetrazole-induced convulsion, motor coordination in the rotarod test, or nociceptive response in the tail pinch test in group- housed mice. These results suggest that PI-E attenuates pathophysiological changes caused by social isolation stress in mice, and that the GABAergic system is partly involved in the action of PI-E on a social isolation- induced decrease in pentobarbital sleep.