Publication: Pharmacokinetics and ex vivo anti-malarial activity OFsera following a single oral dose of dihydroartemisinin in healthy Thai males
1
Issued Date
1997-12-01
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ISSN
01251562
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2-s2.0-0031301122
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, No.4 (1997), 731-735
Suggested Citation
Kesara Na-Bangchang, Kanungnit Congpoung, Ratawan Ubalee, Aurathai Thanavibul, Peerapan Tan-anya, Juntra Karbwang Pharmacokinetics and ex vivo anti-malarial activity OFsera following a single oral dose of dihydroartemisinin in healthy Thai males. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, No.4 (1997), 731-735. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18023
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Title
Pharmacokinetics and ex vivo anti-malarial activity OFsera following a single oral dose of dihydroartemisinin in healthy Thai males
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Abstract
The pharmacokinetics of dihydroartemisinin (DHA) was studied in eight healthy male Thai subjects after a single oral dose of 300 mg. Absorption of oral DHA was rapid, Cmax of 679 (307-1000) ng/ ml was observed at 1.5 (1-2.5) hours after dosing [median (range)]. Plasma concentrations declined monoexponentially and at 12 hours after administration, the levels were below the detection limit (3 ng/ml). A large variation in the AUC (approximately) 50% was observed. The median (range) AUC was 2010 (636-4079) ng h/ml. The lag time and absorption half-life (t1.2a) were 0.169 (0.111-0.277) hours and 0.709 (0.367-1.118) hours respectively. t1/2z was 1.25(0.79-1.89) hours Vz/f and CL/f were 5.9 (3.5-8.2) 1/kg and 45.3 (28.6-122.8) ml/min/kg, respectively. The pattern of its ex vivo serum activity coincided with the plasma concentrations of DHA.