Publication:
Complete remission of refractory gestational trophoblastic disease with brain metastases treated with multicycle ifosfamide, carboplatin, and etoposide (ICE) and stem cell rescue

1

Issued Date

1997-01-01

Resource Type

Article

ISSN

00908258

DOI

10.1006/gyno.1997.4677

Other identifier(s)

2-s2.0-0031148788

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Gynecologic Oncology. Vol.65, No.2 (1997), 366-369

Suggested Citation

Koen Van Besien, Claire Verschraegen, Rakesh Mehra, Sergio Giralt, Andrzej P. Kudelka, Creighton L. Edwards, Surintip Piamsonboom, Wichai Termrungruanglert, Richard Champlin, John J. Kavanagh Complete remission of refractory gestational trophoblastic disease with brain metastases treated with multicycle ifosfamide, carboplatin, and etoposide (ICE) and stem cell rescue. Gynecologic Oncology. Vol.65, No.2 (1997), 366-369. doi:10.1006/gyno.1997.4677 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18213

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Title

Complete remission of refractory gestational trophoblastic disease with brain metastases treated with multicycle ifosfamide, carboplatin, and etoposide (ICE) and stem cell rescue

Author(s)

Koen Van Besien
 Claire Verschraegen
 Rakesh Mehra
 Sergio Giralt
 Andrzej P. Kudelka
 Creighton L. Edwards
 Surintip Piamsonboom
 Wichai Termrungruanglert
 Richard Champlin
 John J. Kavanagh

Other Contributor(s)

University of Texas MD Anderson Cancer Center
 Mahidol University
 Chulalongkorn University

Abstract

Patients with chemotherapy-refractory gestational trophoblastic disease and brain metastasis are considered to have a very poor prognosis. We present the case of a patient who had failed several chemotherapeutic regimens. Despite transient responses to chemotherapy, she had not achieved a complete remission in 3 years, and had developed systemic disease and recurrent brain metastasis. She was treated with four cycles of high-dose ifosfamide, carboplatin, and etoposide with blood progenitor cell support. She tolerated this regimen well and has obtained a complete remission that is ongoing for 12 months.

Keyword(s)

Medicine

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https://repository.li.mahidol.ac.th/handle/123456789/18213

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Scopus 1991-2000