Publication: Dihydrofolate reductase and antifolate resistance in malaria
Issued Date
1998-12-01
Resource Type
ISSN
13687646
Other identifier(s)
2-s2.0-0000715174
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Mahidol University
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SCOPUS
Bibliographic Citation
Drug Resistance Updates. Vol.1, No.6 (1998), 397-406
Suggested Citation
Worachart Sirawaraporn Dihydrofolate reductase and antifolate resistance in malaria. Drug Resistance Updates. Vol.1, No.6 (1998), 397-406. doi:10.1016/S1368-7646(98)80015-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18273
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Title
Dihydrofolate reductase and antifolate resistance in malaria
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Abstract
The dihydrofolate reductase (DHFR, EC 1.5.1.3) domain of Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is an attractive target of two important antifolate antimalarials: pyrimethamine (Pyr) and cycloguanil (Cyc). Over recent years, knowledge of malarial DHFR and mechanism(s) of antifolate resistance have increased substantially. These observations have provided an important framework for better understanding the molecular basis of antifolate resistance in malaria. This article provides a brief review and update on molecular aspects relevant to antifolate resistance in malaria. © 1998 Harcourt Brace & Co. Ltd All rights reserved.