Publication: Clinical trials prove the safety and efficacy of the probiotic strain Bifidobacterium Bb12 in follow-up formula and growing-up milks
17
Issued Date
1998-09-14
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ISSN
00269298
Other identifier(s)
2-s2.0-7344222021
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Mahidol University
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SCOPUS
Bibliographic Citation
Monatsschrift fur Kinderheilkunde. Vol.146, No.8 SUPPL. 1 (1998)
Suggested Citation
F. Haschke, W. Wang, Guozai Ping, Wandee Varavithya, Amornrath Podhipatr, Florence Rochat, Harriet Link-Amster, Andrea Pfeifer, Erika Diallo-Ginstl, P. Steenhout Clinical trials prove the safety and efficacy of the probiotic strain Bifidobacterium Bb12 in follow-up formula and growing-up milks. Monatsschrift fur Kinderheilkunde. Vol.146, No.8 SUPPL. 1 (1998). Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18475
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Title
Clinical trials prove the safety and efficacy of the probiotic strain Bifidobacterium Bb12 in follow-up formula and growing-up milks
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Abstract
Clinical trials to prove the safety and efficacy of follow-up formulas and growing-up milks fortified with Bifidobacterium strain Bb12 (107-108/g formula powder) are summarized in this report. The strain Bb12 was selected because of its excellent survival during intestinal transit and adhesion to enterocytes. Double-blind, randomized, controlled feeding studies with Bb12 in the U.S., China, and Thailand demonstrated normal growth of healthy children between 4 and 36 months of age and catch-up growth in malnourished children. 'Colonization' with Bb12, which indicates survival during intestinal transit, was confirmed when Bb12 was given with milk-based formulas, but was not satisfactory with soy-based formulas. Feeding the milk- based formula with Bb12 resulted in protection from rotavirus infection, fewer periods with hard bowel movements and a lower incidence of diaper rash. Therefore, using follow-up formulas and growing-up milks with Bifidobacterium strain Bb12 is safe and can prevent diseases frequently seen in both industrialized and developing countries.