Publication: Successful treatment of disseminated BCG infection in a SCID patient with granulocyte colony stimulating factor
2
Issued Date
2008-03-01
Resource Type
ISSN
0125877X
Other identifier(s)
2-s2.0-45349105973
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.26, No.1 (2008), 71-75
Suggested Citation
Wipada Pariyaprasert, Punchama Pacharn, Nualanong Visitsunthorn, Kulkanya Chokephaibulkit, Kleebsabai Sanpakit, Vip Viprakasit, Pakit Vichyanond, Orathai Jirapongsananuruk Successful treatment of disseminated BCG infection in a SCID patient with granulocyte colony stimulating factor. Asian Pacific Journal of Allergy and Immunology. Vol.26, No.1 (2008), 71-75. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19362
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Title
Successful treatment of disseminated BCG infection in a SCID patient with granulocyte colony stimulating factor
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Abstract
Severe combined immunodeficiencies (SCID) are disorders with impairment of humoral and cellular immune functions. The prognosis of disseminated bacillus Calmette-Guérin (BCG) infection in immunocompromised host is unfavorable since response to standard therapy is poor. We report a successful treatment of disseminated BCG infection with granulocyte colony stimulating factor (G-CSF) in a patient with severe combined immunodeficiency. The patient failed to response to intensive anti-tuberculous (anti-TB) therapy. After 2 months of GCSF, in addition to anti-TB treatment, the clinical signs of disseminated BCG infection were improved. Since serious BCG infections in SCID are not uncommon in developing countries, where BCG vaccination is mandatory to all newborns, the combination of G-CSF and anti-TB drugs should be considered in immunocompromised patients with protracted mycobacterial infection.