Publication: Estrogenic activity of the dichloromethane extract from Pueraria mirifica
Issued Date
2008-12-01
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ISSN
0367326X
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2-s2.0-55049110095
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Mahidol University
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SCOPUS
Bibliographic Citation
Fitoterapia. Vol.79, No.7-8 (2008), 509-514
Suggested Citation
N. Sookvanichsilp, N. Soonthornchareonnon, C. Boonleang Estrogenic activity of the dichloromethane extract from Pueraria mirifica. Fitoterapia. Vol.79, No.7-8 (2008), 509-514. doi:10.1016/j.fitote.2008.05.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19863
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Title
Estrogenic activity of the dichloromethane extract from Pueraria mirifica
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Abstract
Pueraria mirifica and its extracts are widely used as the ingredient(s) in many rejuvenating products. Up to now, the extract of P. mirifica roots that has been used in most studies, is the alcoholic extract. In the present study, we investigated the estrogenic activity using uterotropic and MCF-7 cell proliferation models of the dichloromethane extract as well as the water extract which was obtained from partitioning the ethanolic extract. The results indicated that among the three extracts, i.e. the ethanolic extract (PM1), the water extract (PM2) and dichloromethane extract (PM3), PM3 exhibited the most potent estrogenic activity in both models, followed by PM1. The extracts produced uterotropic activity associated with the increase of water content while uterotropic activity of 17β-estradiol was related to the increase of muscle mass. The two isoflavonoids, genistein and daidzein, were not the major active phytoestrogens involving the estrogenic activity of these extracts. © 2008 Elsevier B.V. All rights reserved.