Publication:
Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides

Issued Date

2003-05-01

Resource Type

Article

ISSN

01633864

DOI

10.1021/np0205598

Other identifier(s)

2-s2.0-0037513316

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Natural Products. Vol.66, No.5 (2003), 709-711

Suggested Citation

Palangpon Kongsaeree, Samran Prabpai, Nongluksna Sriubolmas, Chanika Vongvein, Suthep Wiyakrutta Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides. Journal of Natural Products. Vol.66, No.5 (2003), 709-711. doi:10.1021/np0205598 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20732

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides

Author(s)

Palangpon Kongsaeree
 Samran Prabpai
 Nongluksna Sriubolmas
 Chanika Vongvein
 Suthep Wiyakrutta

Other Contributor(s)

Mahidol University
 Chulalongkorn University

Abstract

Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (1), 7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (2), and 7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (3) using spectroscopic data.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/20732

Collections

Scopus 2001-2005