Publication: The efficacy of combined mefloquine-artesunate versus mefloquine-primaquine on subsequent development of Plasmodium falciparum gametocytemia
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Issued Date
2003-01-01
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ISSN
00029637
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2-s2.0-0038470888
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.68, No.5 (2003), 620-623
Suggested Citation
Yupin Suputtamongkol, Supat Chindarat, Saowalak Silpasakorn, Suchada Chaikachonpatd, Kimheng Lim, Kittiporn Chanthapakajee, Naparat Kaewkaukul, Visanu Thamlikitkul The efficacy of combined mefloquine-artesunate versus mefloquine-primaquine on subsequent development of Plasmodium falciparum gametocytemia. American Journal of Tropical Medicine and Hygiene. Vol.68, No.5 (2003), 620-623. doi:10.4269/ajtmh.2003.68.620 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20940
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Title
The efficacy of combined mefloquine-artesunate versus mefloquine-primaquine on subsequent development of Plasmodium falciparum gametocytemia
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Abstract
An open randomized controlled study of mefloquine-artesunate and mefloquine-primaquine for the treatment of uncomplicated Plasmodium falciparum malaria was carried out in Kanchanaburi in the Saiyok District in western Thailand. Weekly parasite counts from thick and thin blood films were done for six weeks. The gametocyte carriage rate was calculated and compared between the two treatment groups. Gametocytes on presentation, recrudescent infection, and reinfection were the significant factors associated with subsequent development of gametocytemia. It is the increased propensity of recrudescent infections to produce gametocytes that drives drug resistance. The results of this study confirmed that the complete eradication of asexual forms of P. falciparum by effective antimalarial treatment, but not by combination treatment with primaquine, is the most effective means to prevent subsequent gametocytemia.