Publication: Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera
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Issued Date
2004-02-09
Resource Type
ISSN
00404020
Other identifier(s)
2-s2.0-0742272061
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Mahidol University
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SCOPUS
Bibliographic Citation
Tetrahedron. Vol.60, No.7 (2004), 1517-1523
Suggested Citation
Vichai Reutrakul, Chongkon Krachangchaeng, Patoomratana Tuchinda, Manat Pohmakotr, Thaworn Jaipetch, Chalobon Yoosook, Jittra Kasisit, Samaisukh Sophasan, Kulawee Sujarit, Thawatchai Santisuk Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera. Tetrahedron. Vol.60, No.7 (2004), 1517-1523. doi:10.1016/j.tet.2003.12.010 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21224
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Title
Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera
Abstract
Two new natural cycloartanes, tubiferolide methyl ester (1) and tubiferaoctanolide (2), together with the known coronalolide (3) and coronalolide methyl ester (4) have been isolated from leaves and twigs of Gardenia tubifera. In addition, a new flavone 5,3′,5′-trihydroxy-7, 4′-dimethoxyflavone (5), five known flavones 6-10 and hexacosyl 4′-hydroxy-trans-cinnamate (11) were also obtained from the same source. The structures were assigned on the basis of spectroscopic methods. Compounds 3, 7, 9, and 10 showed significant cytotoxic activities only in P-388 cell line. Compound 1 was cytotoxic against P-388, KB, Col-2 and Lu-1, while 4 was active in P-388 and BCA-1. Compounds 3 and 4 displayed significant anti-HIV activities in the HIV-1RT assay; compound 7 showed moderate activity in this assay. Compounds 5-10 were also found to be active in theΔTat/RevMC 99 syncytium assay. © 2003 Elsevier Ltd. All rights reserved.