Publication: Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord
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Issued Date
1991-05-03
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ISSN
00068993
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2-s2.0-0025907224
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Mahidol University
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SCOPUS
Bibliographic Citation
Brain Research. Vol.547, No.2 (1991), 344-348
Suggested Citation
Danxia Liu, Wipawan Thangnipon, David J. McAdoo Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord. Brain Research. Vol.547, No.2 (1991), 344-348. doi:10.1016/0006-8993(91)90984-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21987
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Title
Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord
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Abstract
The release of glutamate, aspartate, glutamine and asparagine upon impact injury to the rat spinal cord was characterized by sample collection from the site of injury by microdialysis. Injury caused dramatic and long-lasting increases in the concentrations of the excitatory amino acids. Determination of the relationship between unperturbed extracellular levels and the levels of amino acids in the collected fluids indicates that the concentrations of these amino acids were probably high enough to kill neurons for longer than one hour following impact injury to the spinal cord. Increases in the concentrations of the metabolically related non-neurotransmitters asparagine and glutamine were considerably smaller. The latter observations suggest that much of the increase in levels of the excitatory amino acids resulted from neuronal activity rather than from simple damage. © 1991.