Publication:
Diagnosis of melioidosis by means of an ELISA detecting antibodies to Pseudomonas pseudomallei exotoxin. Preliminary assay evaluation

4

Issued Date

1991-01-01

Resource Type

Article

ISSN

15730972
09593993

DOI

10.1007/BF02310916

Other identifier(s)

2-s2.0-0042673244

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

World Journal of Microbiology and Biotechnology. Vol.7, No.1 (1991), 29-36

Suggested Citation

C. J. Smith, M. Jones, D. A.B. Dance, W. Chaowagul, N. J. White Diagnosis of melioidosis by means of an ELISA detecting antibodies to Pseudomonas pseudomallei exotoxin. Preliminary assay evaluation. World Journal of Microbiology and Biotechnology. Vol.7, No.1 (1991), 29-36. doi:10.1007/BF02310916 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22013

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Title

Diagnosis of melioidosis by means of an ELISA detecting antibodies to Pseudomonas pseudomallei exotoxin. Preliminary assay evaluation

Author(s)

C. J. Smith
 M. Jones
 D. A.B. Dance
 W. Chaowagul
 N. J. White

Other Contributor(s)

Faculty of Science and Innovation
 Mahidol University
 John Radcliffe Hospital
 Sappasitthiprasong Hospital
 London School of Hygiene & Tropical Medicine

Abstract

An ELISA system for the detection of human antibodies to Pseudomonas pseudomallei exotoxin is described. Analysis of control sera and sera from patients with culture-positive melioidosis showed that both IgG and IgM antibodies to exotoxin were detectable in patients with melioidosis. This implies that the exotoxin is produced in vivo by P. pseudomallei, and may be involved in the pathogenesis of melioidosis. Furthermore, these rapid and simple assays may prove to be useful for the serodiagnosis of the disease. © 1991, Rapid Communications of Oxford Ltd. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/22013

Collections

Scopus 1991-2000