Journal of the Medical Association of Thailand. Vol.74, No.6 (1991), 327-330
Suggested Citation
P. Jariya, S. Tiewchaloren, K. Mankalanond An in vitro study on mefloquine/quinine in Plasmodium falciparum malaria. Journal of the Medical Association of Thailand. Vol.74, No.6 (1991), 327-330. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22204
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An in vitro study on mefloquine/quinine in Plasmodium falciparum malaria
An in vitro designed for determining sensitivity of Plasmodium falciparum strains isolated from Kanchanaburi Province, to Mefloquine/Quinine combination, was carried out. The MIC values of Mefloquine/Quinine for the P. falciparum strains were found to be 0.075/3.75 to 0.225/11.15 nM/ml. The changes observed following the drug treatment were an enlargement of the space between the outer and the inner limiting membrane of the parasitophorus vacuole. These changes were followed by cytoplasmic degeneration and vacuolation.
