Publication: Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver
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1992-01-31
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03043835
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2-s2.0-0026603318
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Mahidol University
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Cancer Letters. Vol.61, No.3 (1992), 229-232
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W. Thamavit, M. A. Moore, Somsak Ruchirawat, N. Ito (1992). Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22260.
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Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver
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Abstract
The effects of repeated praziquantel administration subsequent to dimethylnitrosamine (DMN) treatment of Syrian hamsters were investigated. The antihelminthic drug was given (200 mg/kg body wt. as a suspension in corn oil, by i.g. intubation) 11 times at 2 week intervals starting at week 4 after initial 20 mg/kg DMN i.p: injections at weeks 0 and 2. Sacrifice at week 28 revealed no differences in either hepatocellular or cholangiocellular lesion development between carcinogen-initiated groups with or without antihelminthic treatment. No lesions were observed in the praziquantel alone or untreated groups. The results thus indicate no promotion potential for praziquantel on nitrosamine-induced lesions in the hamster liver. © 1992.