Publication: Studies on a new antimalarial compound: Pyronaridine
Issued Date
1992-01-01
Resource Type
ISSN
18783503
00359203
00359203
Other identifier(s)
2-s2.0-0026541268
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.86, No.1 (1992), 7-10
Suggested Citation
Chen Chang, Tang Lin-Hua, Chun Jantanavivat Studies on a new antimalarial compound: Pyronaridine. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.86, No.1 (1992), 7-10. doi:10.1016/0035-9203(92)90414-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22302
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Title
Studies on a new antimalarial compound: Pyronaridine
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Abstract
Pyronaridine, a hydroxyanilino-benzonaphthyridine derivative synthesized in 1970, is a new antimalarial compound which has been in use in China for more than 10 years. The drug is highly effective against Plasmodium falciparum and P. vivax. Furthermore, it is efficacious in combatting chloroquine-resistant strains of falciparum malaria both in vitro and in vivo, in human patients. Extensive field studies involving several thousand cases have shown that pyronaridine has promising therapeutic value in the treatment of malarial infection, including chloroquine-resistant infections. Pyronaridine given orally, intramuscularly or by intravenous drip is not only effective against malaria but also has low toxicity. © Oxford University Press.