Publication: Pharmacokinetics of mefloquine in children aged 6 to 24 months
Issued Date
1992-10-01
Resource Type
ISSN
21070180
03787966
03787966
Other identifier(s)
2-s2.0-0027103175
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Drug Metabolism and Pharmacokinetics. Vol.17, No.4 (1992), 275-279
Suggested Citation
V. Singhasivanon, T. Chongsuphajaisiddhi, A. Sabcharoen, P. Attanath, H. K. Webster, W. H. Wernsdorfer, U. K. Sheth, I. Djaja Lika Pharmacokinetics of mefloquine in children aged 6 to 24 months. European Journal of Drug Metabolism and Pharmacokinetics. Vol.17, No.4 (1992), 275-279. doi:10.1007/BF03190160 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22372
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Title
Pharmacokinetics of mefloquine in children aged 6 to 24 months
Abstract
The study was carried out in 12 children aged 6 months to 2 years, with uncomplicated falciparum malaria admitted to the Hospital for Tropical Diseases, Bangkok. They were treated with mefloquine in the form of MSP (mefloquine 2S0 mg+sulfadoxine 500 mg +pyrimethamine 25 mg) at a single dose of 25 mg mefloquine base/kg body weight All of them were cured (28 days follow-up) with minimal side effects. Pharmacokinetic parameter determination was carried out in 9 cases. The results revealed that MRT, t1/2 and tmax in this study (children 6-24 months old) are comparable to the values in children aged 5-12 years, but shorter than in adult patients. Cmax and AUC in children 6-24 months old are comparable to those in children of 5-12 years, but much higher than in adult patients. Vz/f values in this study are comparable to those in children 5-12 years old, but lower than in adult patients. © 1992 Springer-Verlag.