Publication: Pharmacokinetics of praziquantel in patients with opisthorchiasis
5
Issued Date
1993-12-01
Resource Type
ISSN
00383619
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2-s2.0-0027884928
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.24, No.4 (1993), 717-723
Suggested Citation
K. Na Bangchang, J. Karbwang, S. Pungpak, B. Radomyos, D. Bunnag Pharmacokinetics of praziquantel in patients with opisthorchiasis. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.24, No.4 (1993), 717-723. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22622
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Title
Pharmacokinetics of praziquantel in patients with opisthorchiasis
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Abstract
The pharmacokinetics of praziquantel was investigated in 9 Thai male patients with asymptomatic opisthorchiasis (stool positive) and 9 patients (6 males, 3 females) with moderately advanced infection (hepatomegaly). The geometric means of the pretreatment Opisthorchis viverrini egg count in these patients were 2,950 vs 4,468 eggs per gram of stool. The results indicate the impairment of metabolism of praziquantel in the moderately advanced stage opisthorchiasis. The pharmacokinetics of the drug in these patients during the acute infection was markedly altered when compared with that after recovery and in patients with early stage of the infection. The clearance rate (Cl/f) was significantly reduced [medians and ranges of 106 (43-242) vs 192 (112-692) and 171 (133-427) mL/min/kg] and the t( 1/2 z) and MRT were prolonged [t( 1/2 z): 3.8 (2.0-6.2) vs 2.7 (1.7-4.3) and 2.3 (1.7-2.8) hours; MRT: 6.2 (3.2-11.0) vs 4.6 (2.7-6.2) and 4.5 (2.9-5.1) hours]. In addition, AUC(o-α) was significantly greater [6.0 (2.5-15.6) vs 3.5 (0.6-6.0) and 3.9 (1.6-5.0) μg hour/ml].