Publication: Fine tuning the production of nanosized β-carotene particles using spinning disk processing
Issued Date
2006-10-25
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ISSN
00027863
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2-s2.0-33750381323
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the American Chemical Society. Vol.128, No.42 (2006), 13847-13853
Suggested Citation
Natthinee Anantachoke, Mohamed Makha, Colin L. Raston, Vichai Reutrakul, Nigel C. Smith, Martin Saunders Fine tuning the production of nanosized β-carotene particles using spinning disk processing. Journal of the American Chemical Society. Vol.128, No.42 (2006), 13847-13853. doi:10.1021/ja063545n Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22960
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Title
Fine tuning the production of nanosized β-carotene particles using spinning disk processing
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Abstract
Nanoparticles of trans-β-carotene are accessible using spinning disk processing (SDP), by varying the reaction conditions and the choice of surfactant, macrocyclic amphiphiles, sulfonato-calix[4,5,6,8]arenes, and α,β-cyclodextrins. SDP ensures rapid mixing and fast kinetics, and nanoparticles of the carotene formed in the presence of the calixarenes are stable with respect to extraction of the carotene into an organic solvent, unlike in the presence of the cyclodextrins. Insight into the supramolecular structure of the carotene nanoparticles has also been established. The mean particle sizes (dynamic light scattering, DLS) have been optimized at 40(2) and 56(1) nm and 71.4(6) and 82(1) nm, respectively, for each sulfonato-calix[5,6 and 4,8]arene, whereas the cyclodextrins form nanoparticles with a mean diameter of 71(1) and 68.5(6) nm, respectively. ζ-Potential studies show stability of all the colloidal dispersions at pH > 4 with values below -30 mV. UV-visible spectroscopy shows a blue shift indicative of H-aggregates of the carotene within the nanoparticles. The surface area derived from BET studies is 39.12 m2/g corresponding to particles of 76.7(5) nm in diameter, in agreement with sizes obtained from DLS and TEM measurements. © 2006 American Chemical Society.