Publication: Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza
1
Issued Date
2006-02-01
Resource Type
ISSN
00320943
Other identifier(s)
2-s2.0-33645008064
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.72, No.3 (2006), 255-260
Suggested Citation
Sudarat Homhual, Hong Jie Zhang, Nuntavan Bunyapraphatsara, Tamara P. Kondratyuk, Bernard D. Santarsiero, Andrew D. Mesecar, Angkana Herunsalee, Wongsatit Chaukul, John M. Pezzuto, Harry H.S. Fong Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza. Planta Medica. Vol.72, No.3 (2006), 255-260. doi:10.1055/s-2005-873171 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23091
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Title
Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza
Abstract
A new cyclic 4-hydroxy-dithiosulfonato, bruguiesulfurol (1), as well as two known 4-hydroxydithiolane 1-oxides, brugierol (2) and isobrugierol (3) were isolated from the flowers of Bruguiera gymnorrhiza. With stably-transfected HepG2 cells, the three isolates activated antioxidant response element (ARE) luciferase activation with (EC50) values of 56.7, 3.7 and 1.8 μM, respectively. Compounds 2 and 3 also inhibited phorbol ester-induced NF-κB (nuclear factor-κB) luciferase activity with IC50 values of 85.0 and 14.5 μM, respectively. In addition, compound 2 inhibited enzyme cyclooxygenase-2 (COX-2) activity with an IC50 value of 6.1 μM. The structures of these isolates were determined by spectral data, and that of compound 1 was confirmed by X-ray crystallographic analysis. © Georg Thieme Verlag KG Stuttgart.