Publication: Increased HIV-DNA load in CCR5-negative lymphocytes without viral phenotypic change
1
Issued Date
2006-04-10
Resource Type
ISSN
10960341
00426822
00426822
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2-s2.0-33646051566
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Mahidol University
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SCOPUS
Bibliographic Citation
Virology. Vol.347, No.2 (2006), 372-378
Suggested Citation
Maitree Pakarasang, Chantapong Wasi, Surapol Suwanagool, Amphan Chalermchockcharoenkit, Prasert Auewarakul Increased HIV-DNA load in CCR5-negative lymphocytes without viral phenotypic change. Virology. Vol.347, No.2 (2006), 372-378. doi:10.1016/j.virol.2005.12.003 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23341
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Title
Increased HIV-DNA load in CCR5-negative lymphocytes without viral phenotypic change
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Abstract
We have previously described a selective increase in HIV-DNA content in CCR5-negative lymphocytes from late stage HIV-infected patients. Here, we show that this increase occurred even in the absence of viral phenotypic switching from CCR5- to CXCR4-tropic. This leads us to hypothesize that early and late CCR5-tropic viruses might be different in the ability to infect CCR5-low or -negative cells. We compared a set of early CCR5-tropic viruses with low viral DNA content in CCR5-negative cells to a set of late CCR5-tropic viruses with high viral DNA content in CCR5-negative cells. We could not find any significant differences between the two sets of viruses in the aspects of relative infectivity in CCR5-low cells and the level of inhibition by β-chemokine. This suggested that there may be some changes in cellular phenotype or environment that allows an expansion of susceptible cell population in late stages HIV infection. Understanding these changes may provide a novel approach for HIV therapy. © 2005 Elsevier Inc. All rights reserved.