Publication: In vitro motility of a population of clinical Burkholderia Pseudomallei isolates
Issued Date
2006-10-11
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-33749436559
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.89, No.9 (2006), 1506-1510
Suggested Citation
Khaemaporn Boonbumrung, Vanaporn Wuthiekanun, Sirirat Rengpipat, Nicholas P J Day, Sharon J. Peacock In vitro motility of a population of clinical Burkholderia Pseudomallei isolates. Journal of the Medical Association of Thailand. Vol.89, No.9 (2006), 1506-1510. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23549
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Title
In vitro motility of a population of clinical Burkholderia Pseudomallei isolates
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Abstract
Melioidosis, a serious infection caused by Burkholderia pseudomallei, is a leading cause of community-acquired sepsis in Northeast Thailand, and the commonest cause of death from community-acquired pneumonia in the Top End of Northern Australia. The causative organism is a Gram-negative, motile bacillus that is a facultative intracellular pathogen. B. pseudomallei flagella have been proposed as a possible vaccine candidate and putative virulence determinant. Flagella expression was highly conserved for 205 clinical B. pseudomallei isolates, as defined by in vitro swim and swarm motility assays. No association was found between motility and clinical factors including bacteremia and death.