Publication: A comparison of the efficacy of sublingual and oral misoprostol 400 microgram in the management of early pregnancy failure: A randomized controlled trial
Issued Date
2006-10-01
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-33846652865
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.89, No.SUPPL. 4 (2006)
Suggested Citation
Orada Patamasingh Na Ayudhaya, Yongyoth Herabutya, Boonsri Chanrachakul, Nathpong Israngura Na Ayuthaya, Pratak O-Prasertsawat A comparison of the efficacy of sublingual and oral misoprostol 400 microgram in the management of early pregnancy failure: A randomized controlled trial. Journal of the Medical Association of Thailand. Vol.89, No.SUPPL. 4 (2006). Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23555
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Title
A comparison of the efficacy of sublingual and oral misoprostol 400 microgram in the management of early pregnancy failure: A randomized controlled trial
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Abstract
Objective: To compare repeated doses of sublingual with oral misoprostol in the medical management of early pregnancy failure. Material and Method: One hundred and thirty eight women with a period of gestation less than 20 week calculated by her last menstrual period and less than 12 weeks by size were sequentially allocated to two groups to receive either 400 μg of misoprostol orally or sublingually every 4 hours until termination of pregnancy was completed. Results: There is no difference in the mean induction to abortion interval. Fever and chill were more common in sublingual group compared with oral group. The other adverse effects were similar and included nausea, vomiting, diarrhea, abdominal pain, and headache. Conclusion: Sublingual misoprostol is as effective as oral route. Most adverse effects are similar in both groups except fever was more common in sublingual group.