Publication: Risk factors for strongyloidiasis hyperinfection and clinical outcomes
Issued Date
2006-09-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-33751581211
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.5 (2006), 875-884
Suggested Citation
Nakhon Asdamongkol, Prapaporn Pornsuriyasak, Somnuek Sungkanuparph Risk factors for strongyloidiasis hyperinfection and clinical outcomes. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.5 (2006), 875-884. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23623
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Risk factors for strongyloidiasis hyperinfection and clinical outcomes
Other Contributor(s)
Abstract
Strongyloidiasis, caused by Strongyloides stercoralis, consists of various clinical syndromes. Strongyloidiasis hyperinfection leads to morbidity and mortality particularly in immunocompromized patients. This study aimed to determine the risk factors for Strongyloidiasis hyperinfection and clinical outcomes. The medical records for hospitalized patients infected with S. stercoralis at Ramathibodi Hospital during 1994-2005 were retrospectively reviewed. Risk factors for Strongyloidiasis hyperinfection were determined. There were 123 episodes of Strongyloidiasis in 111 patients. The mean age was 46.8±17.8 years; 61% were males, Of 123 episodes, 37 (30.1%) had Strongyloidiasis hyperinfection; the others had chronic Strongyloidiasis. All the patients with Strongyloidiasis hyperinfection and 88.3% of those with chronic Strongyloidiasis were immunocompromized (p=0.032); 89.2% of the former and 55.8% of the latter had received corticosteroids (p<0.001). There were no significant differences in the type of immunocompromized host and the corticosteroid dosage between the two groups (p>0.05). The hyperinfection group had a lower mean serum protein (p=0.026) and albumin (p=0.027) but a higher frequency of sepsis (p=0.029), asthma-like symptoms (p=0.025), adult respiratory distress syndrome (p=0.026), and a longer duration of treatment (p=0.004). By logistic regression, corticosteroids use was a risk factor for hyperinfection (OR=6.5, 95%Cl=2.1-20.0, p=0.001). Most of the patients were treated with albendazole or thiabendazole, with a cure rate of 76.9%, whereas other recent cases treated with ivermectin had an average cure rate of 83.3%. The overall mortality rate was 8.1%.