Publication: Dissolution improvement of high drug-loaded solid dispersion
Issued Date
2006-06-02
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ISSN
15309932
15309932
15309932
DOI
Other identifier(s)
2-s2.0-33745080296
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Mahidol University
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SCOPUS
Bibliographic Citation
AAPS PharmSciTech. Vol.7, No.2 (2006)
Suggested Citation
Siriporn Okonogi, Satit Puttipipatkhachorn Dissolution improvement of high drug-loaded solid dispersion. AAPS PharmSciTech. Vol.7, No.2 (2006). doi:10.1208/pt070231 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23904
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Title
Dissolution improvement of high drug-loaded solid dispersion
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Abstract
This study focused on an investigation of a high drug-loaded solid dispersion system consisting of drug, carrier, and surfactant. Solid dispersions of a water-insoluble ofloxacin (OFX) with polyethylene glycol (PEG) of different molecular weights, namely binary solid dispersion systems, were prepared at drug to carrier not less than 5:5. Polysorbate 80, a nonionic surfactant, was incorporated into the binary solid dispersion systems as the third component to obtain the ternary solid dispersion systems. The powder x-ray diffraction and differential scanning calorimetric studies indicated that crystalline OFX existed in the solid dispersions with high drug loading. However, a decreased crystallinity of the solid dispersions obtained revealed that a portion of OFX was in an amorphous state. The results indicated a remarkably improved dissolution of drug from the ternary solid dispersion systems when compared with the binary solid dispersion systems. This was because of polysorbate 80, which improved wettability and solubilized the non-molecularly dispersed or crystalline fraction of OFX. Copyright ©2006. All Rights Reserved.