Publication: Body fluid proteomics for biomarker discovery: Lessons from the past hold the key to success in the future
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Issued Date
2007-12-01
Resource Type
ISSN
15353893
Other identifier(s)
2-s2.0-38049014294
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Proteome Research. Vol.6, No.12 (2007), 4549-4555
Suggested Citation
David M. Good, Visith Thongboonkerd, Jan Novak, Jean Loup Bascands, Joost P. Schanstra, Joshua J. Coon, Anna Dominiczak, Harald Mischak Body fluid proteomics for biomarker discovery: Lessons from the past hold the key to success in the future. Journal of Proteome Research. Vol.6, No.12 (2007), 4549-4555. doi:10.1021/pr070529w Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24076
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Title
Body fluid proteomics for biomarker discovery: Lessons from the past hold the key to success in the future
Abstract
Sparked by the article from Lescuyer and colleagues in a recent issue, we aim here to further encourage interest in and discussion of clinically relevant biomarker research. We express our view on proteomics for biomarker discovery by addressing multiple relevant issues, including the inherent differences between biological fluids (and how these differences affect current analytical approaches) and experimental design to maximize the efficiency of moving from the bench to the bedside. Herein, we also include suggestions for definition of the term "biomarker", based on the use of a set of universal characterization/validation requirements, and illustrate several recent examples of successful transitions of benchtop proteomic studies work to clinical practice. © 2007 American Chemical Society.