Publication:
Determination of paracetamol and orphenadrine citrate in pharmaceutical tablets by modeling of spectrophotometric data using partial least-squares and artificial neural networks

Issued Date

2007-10-01

Resource Type

Article

ISSN

13475231
00316903

DOI

10.1248/yakushi.127.1723

Other identifier(s)

2-s2.0-34848904762

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Yakugaku Zasshi. Vol.127, No.10 (2007), 1723-1729

Suggested Citation

Lawan Sratthaphut, Nongluck Ruangwises Determination of paracetamol and orphenadrine citrate in pharmaceutical tablets by modeling of spectrophotometric data using partial least-squares and artificial neural networks. Yakugaku Zasshi. Vol.127, No.10 (2007), 1723-1729. doi:10.1248/yakushi.127.1723 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24105

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Title

Determination of paracetamol and orphenadrine citrate in pharmaceutical tablets by modeling of spectrophotometric data using partial least-squares and artificial neural networks

Author(s)

Lawan Sratthaphut
 Nongluck Ruangwises

Other Contributor(s)

Mahidol University

Abstract

The estimation of paracetamol and orphenadrine citrate in a multicomponent pharmaceutical dosage form by spectrophotometric method has been reported. Because of highly interference in the spectra and the presence of non-linearity caused by the analyte concentrations which deviate from Beer and Lambert's law, partial least-squares (PLS) and artificial neural networks (ANN) techniques were used for the calibration. A validation set of spiked samples was employed for testing the accuracy and precision of the methods. Reasonably good recoveries were obtained with PLS for paracetamol and the use of an ANN allowed the estimation of orphenadrine citrate, a minor component which could not be adequately modeled by PLS. Three production batches of a commercial sample were analysed, and there was statistically no significant difference (P<0.05) between the results with the proposed method and those obtain with the official comparative method. © 2007 The Pharmaceutical Society of Japan.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

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https://repository.li.mahidol.ac.th/handle/123456789/24105

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Scopus 2006-2010