Publication: Drug solubility in phospholipid carrier as a predictive parameter for drug recovery in microparticles produced by the aerosol solvent extraction system (ASES) process
Issued Date
2007-09-01
Resource Type
ISSN
15205762
03639045
03639045
Other identifier(s)
2-s2.0-34648818909
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Mahidol University
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SCOPUS
Bibliographic Citation
Drug Development and Industrial Pharmacy. Vol.33, No.9 (2007), 932-944
Suggested Citation
Narong Sarisuta, Sarinnate Kunastitchai, Lars Pichert, Bernd W. Müller Drug solubility in phospholipid carrier as a predictive parameter for drug recovery in microparticles produced by the aerosol solvent extraction system (ASES) process. Drug Development and Industrial Pharmacy. Vol.33, No.9 (2007), 932-944. doi:10.1080/03639040601128670 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24130
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Title
Drug solubility in phospholipid carrier as a predictive parameter for drug recovery in microparticles produced by the aerosol solvent extraction system (ASES) process
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Abstract
The solubility of various drugs in a constant ratio of phosphatidylcholine- cholesterol carrier were studied to investigate their influence on drug recovery in drug-lipid microparticles produced by the aerosol solvent extraction system (ASES) process. Solubility of the drugs in such lipid carrier were determined by using differential scanning calorimetry and confirmed by X-ray powder diffraction study. The results showed that drug possessing relatively high solubility in the lipid carrier used could lead to a higher amount of drug recovered in the drug-lipid microparticles produced. However, too high amount of dissolved drug imposed an adverse effect on the solidification of the lipid carrier during ASES processing, which led to partial film formation in the production column and hence a lower yield of microparticles. Such adverse effect was not the case for the drugs with low solubility in the carrier but there was an incomplete recovery of drug in the produced microparticles due to the partial extraction by the supercritical gas instead. The maximum amount of drug recovered in the ASES-prepared microparticles was found to correlate to the solubility of drug in the lipid carrier so that it might be utilized as a predictive parameter for determining the amount of drug to be incorporated into the microparticles. Copyright © Informa Healthcare USA, Inc.