Publication: Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery
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2007-08-28
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2-s2.0-34548129923
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Mahidol University
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Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. (2007), 1020-1023
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Usawadee Sakulkhu, Sanitra Jarupaiboon, Alongkot Trithong, Sirapat Prathontep, Varaporn Janyaprasert, Satit Puttipipatkhachorn, Uracha Ruktanonchai (2007). Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24397.
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Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery
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Abstract
Solid lipid nanoparticles (SLNs) recently gain attention as colloidal drug carriers, for both intravenous and dermal delivery. The present study focused on the preparation and some characterization of SLN associated with gamma-oryzanol of the specialized delivery systems. The nanoparticles, containing Dynasan 114 as lipid and Pluronic® F68 as emulsifying agent were prepared by hot homogenization method. Particle sizes of SLNs were in suitable range and homogenous. Moreover, SLNs containing gamma-oryzanol are stable for investigated time as suggested by size, pH, % entrapment efficiency and DSC. Moreover, HPLC chromatograms indicated that no degradation was observed within the investigated period. Therefore chosen composition and method of preparation benefit the stability of the nanoparticles, which is suitable for transdermal skin penetration. © 2007 IEEE.