Publication: A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries
Issued Date
2007-09-01
Resource Type
ISSN
01678140
Other identifier(s)
2-s2.0-34548427030
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Mahidol University
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SCOPUS
Bibliographic Citation
Radiotherapy and Oncology. Vol.84, No.3 (2007), 314-319
Suggested Citation
Takashi Nakano, Shingo Kato, Jianping Cao, Juying Zhou, Raden Susworo, Nana Supriana, Shinichiro Sato, Tatsuya Ohno, Hisao Suto, Yuzuru Nakamura, Chul Koo Cho, Fuad B. Ismail, Miriam J.C. Calaguas, Rey H. de los Reyes, Yaowalak Chansilpa, Kullathom Thephamongkhol, Nguyen Ba Duc, To Anh Dung, Hirohiko Tsujii A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries. Radiotherapy and Oncology. Vol.84, No.3 (2007), 314-319. doi:10.1016/j.radonc.2007.05.012 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24780
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Title
A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries
Author(s)
Other Contributor(s)
Gunma University Faculty of Medicine
National Institute of Radiological Sciences Chiba
Soochow University
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Matsudo City Hospital
Saitma Medical University Faculty of Medicine
Korea Cancer Center Hospital
Hospital Universiti Kebangsaan Malaysia
St. Luke's Medical Center Quezon City
Jose R. Reyes Memorial Medical Center
Mahidol University
National Cancer Institute Hanoi
National Institute of Radiological Sciences Chiba
Soochow University
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Matsudo City Hospital
Saitma Medical University Faculty of Medicine
Korea Cancer Center Hospital
Hospital Universiti Kebangsaan Malaysia
St. Luke's Medical Center Quezon City
Jose R. Reyes Memorial Medical Center
Mahidol University
National Cancer Institute Hanoi
Abstract
Purpose: Radiotherapy differed widely in east and south-east Asia because of technical, cultural, and socio-economic differences. With the purpose of standardizing radiotherapy for cervical cancer in the region, an international clinical study was conducted. Materials and methods: Eleven institutions in eight Asian countries participated in the study. Between 1996 and 1998, 210 patients with stage IIIB cervical cancer were enrolled. Patients were treated with a combination of external beam radiotherapy (total dose, 50 Gy) and either high-dose-rate (HDR) or low-dose-rate (LDR) intracavitary brachytherapy (ICBT) according to the institutional practice. The planned point A dose was 20-28 Gy/4 fractions for HDR-ICBT and 30-40 Gy/1-2 fractions for LDR-ICBT. Results: Hundred patients were treated with HDR-ICBT and 110 were treated with LDR-ICBT. The ICBT doses actually delivered to point A ranged widely: 12-32 Gy in the HDR group and 26-52.7 Gy in the LDR group. The 5-year follow-up rate among the countries differed greatly, from 29% to 100%. The 5-year major complication rates were 6% in the HDR group and 10% in the LDR group. The 5-year overall survival rates were 51.1% in the HDR group and 57.5% in the LDR group. Conclusions: Although there were several problems with treatment compliance and patients' follow-up, the study suggests that the protocols provided favorable outcomes with acceptable rates of late complications in the treatment of advanced cervical cancer in east and south-east Asia. © 2007 Elsevier Ireland Ltd. All rights reserved.