Publication:
AML1 mutation and its coexistence with different transcription factor gene families in de novo acute myeloid leukemia: Redundancy or synergism

2

Issued Date

2007-06-01

Resource Type

Article

ISSN

03906078

DOI

10.3324/haematol.10914

Other identifier(s)

2-s2.0-34347211790

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Haematologica. Vol.92, No.6 (2007), 861-862

Suggested Citation

Chirayu U. Auewarakul, Amporn Leecharendkeat, Chintana Tocharoentanaphol, Orathai Promsuwicha, Narongrit Sritana, Wanna Thongnoppakhun AML1 mutation and its coexistence with different transcription factor gene families in de novo acute myeloid leukemia: Redundancy or synergism. Haematologica. Vol.92, No.6 (2007), 861-862. doi:10.3324/haematol.10914 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24864

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Title

AML1 mutation and its coexistence with different transcription factor gene families in de novo acute myeloid leukemia: Redundancy or synergism

Author(s)

Chirayu U. Auewarakul
 Amporn Leecharendkeat
 Chintana Tocharoentanaphol
 Orathai Promsuwicha
 Narongrit Sritana
 Wanna Thongnoppakhun

Other Contributor(s)

Mahidol University
 Chulabhorn Research Institute

Abstract

AML1 mutations were identified in 6.3% of AML patients with chromosomal translocations involving CBF, PML-RARα, HOX, or ETS transcription factor (TF) gene families. Rare chromosomal abnormalities, t(16;21) and t(7;11), were also found. This study represents the first series to demonstrate the coexistence of known and novel AML1 mutations with different TF gene mutations. Although the occurrence of two TF gene mutations may appear unnecessary, the possible synergistic mechanism between different TF gene families cannot be excluded and needs to be further explored.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/24864

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Scopus 2006-2010