Publication: Glucose-6-phosphate dehydrogenase deficiency in Thailand; its significance in the newborn
Issued Date
1999-12-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0347181274
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.30, No.SUPPL. 2 (1999), 75-78
Suggested Citation
Voravarn S. Tanphaichitr Glucose-6-phosphate dehydrogenase deficiency in Thailand; its significance in the newborn. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.30, No.SUPPL. 2 (1999), 75-78. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25493
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Glucose-6-phosphate dehydrogenase deficiency in Thailand; its significance in the newborn
Author(s)
Other Contributor(s)
Abstract
The prevalence of G6PD deficiency in Thai males ranges from 3-18% depending upon the geographic region. GhPD ""Mahidol" (163 Gly → Ser) is the most commun variant found in the Thai population. Almost all affected Thai individuals are not anemic and are asymptomatic. Severe acute intravascular hemolysis is occasionally seen, for instance, in those cases who have a viral infection, bacterial infection or have been exposed to chemicals or drugs. In Thailand, diagnosis of G6PD deficiency is usually made only in symptomatic cases. Neonatal screening of G6PD deficiency is not practiced nationwide, though studies have been done in several institutes. The assessment of G6PD activity in the newborn is mostly in order to find out the cause of neonatal jaundice. In our experience and that of others, G6PD deficient newborn are more prone to develop neonatal jaundice which is, on its own, no more severe than jaundice from other causes. Kernicterus due to G6PD deficiency, though still seen, is now very rare. Awareness of the hazard of hyperbilirubinemia, whatever the cause, along with active management is needed to prevent the occurrence of kernicterus. Neonatal screening is useful to detect abnormalities in the newborn. Weighing of the cost and benefit of neonatal screening should be made and the families of patients should be offered proper education and counseling to help them understand their babies' condition.