Publication:
Investigations of incidence of pretreatment, drug sensitivity in vitro, and plasma levels of pyrimethamine in patients with multidrug resistant falciparum malaria following the three combination regimens of artemether/pyrimethamine

1

Issued Date

1999-06-01

Resource Type

Article

ISSN

01251562

Other identifier(s)

2-s2.0-0033139810

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Southeast Asian Journal of Tropical Medicine and Public Health. Vol.30, No.2 (1999), 220-224

Suggested Citation

Pongsri Tippawangkosol, Kesara Na-Bangchang, Ratawan Ubalee, Kanungnit Congpuong, Jerapat Sirichaisinthop, Juntra Karbwang Investigations of incidence of pretreatment, drug sensitivity in vitro, and plasma levels of pyrimethamine in patients with multidrug resistant falciparum malaria following the three combination regimens of artemether/pyrimethamine. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.30, No.2 (1999), 220-224. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25641

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Title

Investigations of incidence of pretreatment, drug sensitivity in vitro, and plasma levels of pyrimethamine in patients with multidrug resistant falciparum malaria following the three combination regimens of artemether/pyrimethamine

Author(s)

Pongsri Tippawangkosol
 Kesara Na-Bangchang
 Ratawan Ubalee
 Kanungnit Congpuong
 Jerapat Sirichaisinthop
 Juntra Karbwang

Other Contributor(s)

Mahidol University
 Thailand Ministry of Public Health

Abstract

The study was carried out to investigate the status of in vitro susceptibility of Plasmodium falciparum to pyrimethamine (PYR) in multidrug resistant area of the Thai-Myanmar border, the incidence of unregulated use of the combination of PYR with sulfadoxine (Fansidar®) in this area and the relevance of pharmacodynamic and pharmacokinetic factors in determining the treatment outcome from the three combination regimens of ART/PYR (1-, 2- and 3-day regimens), in patients with acute uncomplicated falciparum malaria. The majority of patients had baseline PYR concentrations in the range of 1-100 (50.6%) or 100-500 (34.8%) ng/ml, while concentrations of more than 500 ng/ml were found in only 1.1%. All of the isolates exhibited high grade resistance to PYR with the minimum inhibition concentration (MIC) of as high as 10-5 M. No association was observed between treatment outcome and the presence of baseline plasma PYR concentrations. In addition, lack of association between plasma concentrations during the acute phase (day-1 and -2) and treatment outcome was found.

Keyword(s)

Medicine

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https://repository.li.mahidol.ac.th/handle/123456789/25641

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