Publication: Guava leaf extract and topical haemostasis
4
Issued Date
2000-09-09
Resource Type
ISSN
0951418X
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2-s2.0-0033837785
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytotherapy Research. Vol.14, No.5 (2000), 388-391
Suggested Citation
P. Jaiarj, Y. Wongkrajang, S. Thongpraditchote, P. Peungvicha, N. Bunyapraphatsara, N. Opartkiattikul Guava leaf extract and topical haemostasis. Phytotherapy Research. Vol.14, No.5 (2000), 388-391. doi:10.1002/1099-1573(200008)14:5<388::AID-PTR638>3.0.CO;2-K Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26359
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Title
Guava leaf extract and topical haemostasis
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Abstract
The effects of guava leaf extract on the bleeding time and the three main mechanisms of haemostasis: vasoconstriction, platelet aggregation and blood coagulation, were investigated. The water extract of guava leaves did not shorten bleeding times in rats. Guava leaf extract potentiated the vascular muscle contraction induced in rabbits by phenylephrine, and when given alone it stimulated human platelet aggregation in vitro in a dose-dependent manner. On the other hand, it significantly prolonged blood coagulation; activated partial thromboplastin time (APTT) test (p < 0.05). The higher the concentration of the extract, the longer APTT was observed. Thus, a water extract of guava leaves showed ambiguous effects on the haemostasis system. Guava leaf extract did not affect bleeding times, it stimulated vasoconstriction and platelet aggregation but it inhibited blood coagulation. Therefore, guava leaf extract is not recommended as a haemostatic agent. Copyright (C) 2000 John Wiley and Sons, Ltd.