Publication:
C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene

1

Issued Date

2001-12-20

Resource Type

Article

ISSN

00222623

DOI

10.1021/jm0103007

Other identifier(s)

2-s2.0-0035924213

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Medicinal Chemistry. Vol.44, No.26 (2001), 4688-4695

Suggested Citation

S. Ekthawatchai, S. Kamchonwongpaisan, P. Kongsaeree, B. Tarnchompoo, Y. Thebtaranonth, Y. Yuthavong C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene. Journal of Medicinal Chemistry. Vol.44, No.26 (2001), 4688-4695. doi:10.1021/jm0103007 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26424

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Title

C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene

Author(s)

S. Ekthawatchai
 S. Kamchonwongpaisan
 P. Kongsaeree
 B. Tarnchompoo
 Y. Thebtaranonth
 Y. Yuthavong

Other Contributor(s)

Mahidol University
 Thailand National Center for Genetic Engineering and Biotechnology

Abstract

Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grgnard reagents to artemisitene provided C-16-derived artemisinin monomers, dmers, trimers, and tetramers whose antimalarial and cytotoxic have been evaluated.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/26424

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Scopus 2001-2005