Publication: A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata
Issued Date
2001-04-26
Resource Type
ISSN
00320943
Other identifier(s)
2-s2.0-0035053787
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.67, No.3 (2001), 279-281
Suggested Citation
S. Boonphong, P. Kittakoop, M. Isaka, P. Palittapongarnpim, A. Jaturapat, K. Danwisetkanjana, M. Tanticharoen, Y. Thebtaranonth A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata. Planta Medica. Vol.67, No.3 (2001), 279-281. doi:10.1055/s-2001-11997 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26465
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Title
A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata
Abstract
Bioassay-guided fractionation of the cell extract of the insect pathogenic fungus Aschersonia tubulata BCC 1785 led to the isolation of dustanin (1), 3β,15α,22-trihydroxyhopane (3), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-diene-3β-ol (6), together with the new 3β-acetoxy-15α,22-dihydroxyhopane (4). Chemical structures of these compounds were elucidated by spectral analyses as well as chemical transformation. Compounds I and 4 exhibited antimycobacterial activity with the minimum inhibitory concentration (MIC) of 12:5 μg/ml.