Publication:
A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata

1

Issued Date

2001-04-26

Resource Type

Article

ISSN

00320943

DOI

10.1055/s-2001-11997

Other identifier(s)

2-s2.0-0035053787

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Planta Medica. Vol.67, No.3 (2001), 279-281

Suggested Citation

S. Boonphong, P. Kittakoop, M. Isaka, P. Palittapongarnpim, A. Jaturapat, K. Danwisetkanjana, M. Tanticharoen, Y. Thebtaranonth A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata. Planta Medica. Vol.67, No.3 (2001), 279-281. doi:10.1055/s-2001-11997 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26465

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Title

A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata

Author(s)

S. Boonphong
 P. Kittakoop
 M. Isaka
 P. Palittapongarnpim
 A. Jaturapat
 K. Danwisetkanjana
 M. Tanticharoen
 Y. Thebtaranonth

Other Contributor(s)

Naresuan University
 Thailand National Center for Genetic Engineering and Biotechnology
 Mahidol University

Abstract

Bioassay-guided fractionation of the cell extract of the insect pathogenic fungus Aschersonia tubulata BCC 1785 led to the isolation of dustanin (1), 3β,15α,22-trihydroxyhopane (3), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-diene-3β-ol (6), together with the new 3β-acetoxy-15α,22-dihydroxyhopane (4). Chemical structures of these compounds were elucidated by spectral analyses as well as chemical transformation. Compounds I and 4 exhibited antimycobacterial activity with the minimum inhibitory concentration (MIC) of 12:5 μg/ml.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Medicine
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/26465

Collections

Scopus 2001-2005