Publication: Survey of reverse transcriptase from the heterosexual epidemic of human immunodeficiency virus type 1 CRF01_AE in Thailand from 1990 to 2000
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2001-07-20
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08892229
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2-s2.0-0034835567
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item.page.oaire.edition
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Mahidol University
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AIDS Research and Human Retroviruses. Vol.17, No.11 (2001), 1077-1081
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Sunee Sirivichayakul, Wasan Chantratita, Ruengpung Sutthent, Kiat Ruxrungtham, Praphan Phanuphak, Robert B. Oelrichs (2001). Survey of reverse transcriptase from the heterosexual epidemic of human immunodeficiency virus type 1 CRF01_AE in Thailand from 1990 to 2000. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26561.
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Survey of reverse transcriptase from the heterosexual epidemic of human immunodeficiency virus type 1 CRF01_AE in Thailand from 1990 to 2000
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Abstract
Genetic diversity of the HIV-1 envelope gene has shown a steady increase over time in the Thai and other regional epidemics. A serial survey of subtype CRF01_AE polymerase gene (RT) diversity in Thailand was performed, using 48 novel and 15 reported sequences covering the period 1990-2000. These sequences were gathered from individuals whose sole risk factor for infection was heterosexual contact. By contrast to envelope, diversity was low and, despite a 40% increase early in the epidemic, has remained static since 1996. These results indicate that epidemic HIV-1 may be constrained within defined limits of genetic diversity at least in some genomic regions. © 2001 Mary Ann Liebert, Inc.