Publication: Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria
Issued Date
2001-01-01
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ISSN
00359203
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2-s2.0-0035295408
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Mahidol University
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SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.95, No.2 (2001), 179-182
Suggested Citation
Mayfong Mayxay, Sasithon Pukrittayakamee, Kesinee Chotivanich, Sornchai Looareesuwan, Nicholas J. White Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.95, No.2 (2001), 179-182. doi:10.1016/S0035-9203(01)90156-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26592
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Title
Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria
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Abstract
The potential for Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) dipstick tests to predict antimalarial treatment failure was investigated in a prospective study in Thailand of 38 patients admitted with severe malaria and 54 hospitalized with uncomplicated P. falciparum infections. Of these, 40 had subsequent recrudescence of their infections. Overall, 89% of patients with severe malaria and 61% of patients with uncomplicated malaria had positive PfHRP-2 dipstick tests for >2 weeks following the start of treatment. Persistence was correlated positively with admission parasite counts, PfHRP-2 intensity scores and disease severity. PfHRP-2 tests which remained positive for >2 weeks and PfHRP-2 reactive intensity scores on admission, at day 7 and day 14 did not predict treatment failure independent of admission parasitaemia. Freezing and thawing the blood samples did not significantly affect PfHRP-2 results tested by the dipstick technique. The PfHRP-2 dipstick test provides a useful indicator of recent severe malaria, but does not predict the therapeutic response.