Ipsilateral knee synovitis and pain after femoral shaft fracture and osteosynthesis was studied in 73 patients - 11 females and 62 males. All had isolated closed fracture of the femoral shaft without direct injury to the knee. Synovitis was found in 12 patients (16.4%) and 9 patients (12.3%) had significant knee pain which retarded rehabilitation of the knee function. The synovitis and pain related to the severity of injury and surgical approach. Prevention of this condition should be studied to promote recovery of the patients.