Publication:
Absence of association between the allele coding methionine at position 29 in the N-terminal domain of ICAM-1 (ICAM-1<sup>Kilifi</sup>) and severe malaria in the northwest of Thailand

1

Issued Date

2001-10-08

Resource Type

Article

ISSN

13446304

Other identifier(s)

2-s2.0-0034807718

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Japanese Journal of Infectious Diseases. Vol.54, No.3 (2001), 114-116

Suggested Citation

Jun Ohashi, Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Sornchai Looareesuwan, Katsushi Tokunaga Absence of association between the allele coding methionine at position 29 in the N-terminal domain of ICAM-1 (ICAM-1<sup>Kilifi</sup>) and severe malaria in the northwest of Thailand. Japanese Journal of Infectious Diseases. Vol.54, No.3 (2001), 114-116. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26688

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Title

Absence of association between the allele coding methionine at position 29 in the N-terminal domain of ICAM-1 (ICAM-1<sup>Kilifi</sup>) and severe malaria in the northwest of Thailand

Author(s)

Jun Ohashi
 Izumi Naka
 Jintana Patarapotikul
 Hathairad Hananantachai
 Sornchai Looareesuwan
 Katsushi Tokunaga

Other Contributor(s)

University of Tokyo
 Mahidol University

Abstract

Intercellular adhesion molecule 1 (ICAM-1) is known to be the endothelial receptor for Plasmodium falciparum-infected erythrocytes. Associations of the variant allele coding methionine at position 29 in the N-terminal domain of ICAM-1, ICAM-1Kilifi, with severe malaria have been investigated in African populations, and the results of these investigations have varied widely. In this study, we investigated a possible association between the ICAM-1Kilifi and severe malaria in adult malaria patients living in northwest Thailand. The frequencies of the ICAM-1Kilifi among patients with mild malaria, with non-cerebral severe malaria, and with cerebral malaria were 1.7%, 2.7%, and 2.3%, respectively. This variant showed neither positive nor negative association with severe malaria in Thailand.

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/123456789/26688

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Scopus 2001-2005