Publication: The observation of immunosuppressor(s) derived from cultured tumor cells and its partial neutralization with ok-432
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Issued Date
2001-02-01
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ISSN
01252208
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2-s2.0-14344273286
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.84, No.2 (2001), 212-222
Suggested Citation
Adisak Wongkajornsilp, Rung Arune Luankosolchai, Sukit Huabprasert, Voravut Chanyavanich, Nantasak Tisavipat, Prasit Watanapa The observation of immunosuppressor(s) derived from cultured tumor cells and its partial neutralization with ok-432. Journal of the Medical Association of Thailand. Vol.84, No.2 (2001), 212-222. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26851
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Title
The observation of immunosuppressor(s) derived from cultured tumor cells and its partial neutralization with ok-432
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Abstract
Malignant tumors such as brain tumors have been reported to be associated with immunosuppression caused by certain tumor-secreted cytokines. The reversion of tumor-derived immunosuppression has not been described. The use of OK-432, an immunomodulatory agent prepared from Su-strain of Streptococcus pyogenes A3, to activate peripheral blood mononuclear cells from a patient with glioblastoma multiforme has demonstrated a sharp rise in proliferative response. This proliferative response was compromised in the presence of living and irradiated autogeneic cancer cells. The conditioned media from cultured cells of glioblastoma multiforme, astrocytoma, and cholangiocarcinoma were tested for immunosuppressive ability. We found that conditioned media from 3 of 4 cases of glioblastoma, all 3 cases of astrocytoma, and 1 case of cholangiocarcinoma exhibited immunosuppressive activity toward the proliferative response of allogeneic peripheral blood mononuclear cells to phytohemagglutinin. This is the first report that cholangiocarcinoma produces soluble immunosuppressor(s). Our finding suggested that soluble substance(s) as well as direct cell-cell contact between tumor cells and mononuclear cells play roles in the observed tumor-derived immunosuppression.