Publication: In vitro antineoplastic effect of Ficus hispida L. plant against breast cancer cell lines
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Issued Date
2009-12-01
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ISSN
19960875
19960875
19960875
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2-s2.0-73449133439
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Medicinal Plants Research. Vol.3, No.4 (2009), 255-261
Suggested Citation
B. Pratumvinit, T. Srisapoomi, P. Worawattananon, N. Opartkiattikul, W. Jiratchariyakul, T. Kummalue In vitro antineoplastic effect of Ficus hispida L. plant against breast cancer cell lines. Journal of Medicinal Plants Research. Vol.3, No.4 (2009), 255-261. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26952
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Title
In vitro antineoplastic effect of Ficus hispida L. plant against breast cancer cell lines
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Abstract
Stems of Ficus hispida L. have long been prescribed as one of the constituents in various Thai traditional remedies for cancer therapy. In the present study, crude ethanol extract and its sequential fractions from F. hispida L.: water, methanol: water, methanol and ethyl acetate fraction were tested in vitro against SKBR3, MDA-MB435, MCF7 and T47D human breast cancer cell lines. The results have shown that the methanol extract exhibited antineoplastic activity against T47D cells. The cytotoxic activity was further examined by MTT assay with more dilution, colony forming assay and cell cycle analysis. The IC50 of this extract against T47D cell was 110.3 +/-9.63 μg/mL by MTT assay and colony forming assay confirmed the cell growth inhibition in a dose-dependent manner. Cell cycle analysis demonstrated a rising of apoptotic cell population in herbal treated cells. Therefore, F. hispida L. used in traditional medicine may provide some benefits in the treatment of breast cancer. © 2009 Academic Journals.