Publication: Kinetics and Longevity of Antibody Response to Influenza a H5N1 Virus Infection in Humans
Issued Date
2009-07-01
Resource Type
ISSN
1556679X
15566811
15566811
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2-s2.0-67650355473
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Vaccine Immunology. Vol.16, No.7 (2009), 978-981
Suggested Citation
Rungrueng Kitphati, Phisanu Pooruk, Hatairat Lerdsamran, Siriwan Poosuwan, Suda Louisirirotchanakul, Prasert Auewarakul, Kulkanya Chokphaibulkit, Pirom Noisumdaeng, Pathom Sawanpanyalert, Pilaipan Puthavathana Kinetics and Longevity of Antibody Response to Influenza a H5N1 Virus Infection in Humans. Clinical and Vaccine Immunology. Vol.16, No.7 (2009), 978-981. doi:10.1128/CVI.00062-09 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27193
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Title
Kinetics and Longevity of Antibody Response to Influenza a H5N1 Virus Infection in Humans
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Abstract
Anti-H5N1 antibody was determined by microneutralization, hemagglutination inhibition, and Western blotting assays in serial blood samples collected from eight Thai patients, including four fatal cases and four survivors. The antibody was detected as early as 5 days and, typically, with an increase in titer in paired blood at about 15 days after disease onset. The anti-H5 antibody response was long-lasting, for almost 5 years in cases which can be followed that far. In addition, cross-neutralizing activity to related clade 1 viruses was observed. Copyright © 2009, American Society for Microbiology. All Rights Reserved.