Publication: Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy
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Issued Date
2009-05-01
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ISSN
09598049
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2-s2.0-64349091540
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Cancer. Vol.45, No.7 (2009), 1274-1281
Suggested Citation
Suebwong Chuthapisith, Beverley E. Bean, Gerard Cowley, Jennifer M. Eremin, Srila Samphao, Robert Layfield, Ian D. Kerr, Janice Wiseman, Mohamed El-Sheemy, Thiagarajan Sreenivasan, Oleg Eremin Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy. European Journal of Cancer. Vol.45, No.7 (2009), 1274-1281. doi:10.1016/j.ejca.2008.12.026 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27237
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Title
Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy
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Abstract
Neoadjuvant chemotherapy is used in women who have large or locally advanced breast cancers. However, up to 70% of women who receive neoadjuvant chemotherapy fail to achieve a complete pathological response in their primary tumour (a surrogate marker of long-term survival). Five proteins, previously identified to be linked with chemoresistance in our in vitro experiments, were identified histochemically in pre-treatment core needle biopsies from 40 women with large or locally advanced breast cancers. Immunohistochemical staining with the five proteins showed no single protein to be a predictor of response to chemotherapy. However, pre-treatment breast cancer specimens that were annexin-A2 positive but annexin-A1 negative correlated with a poor pathological response (p = 0.04, Fisher's exact test). The mechanisms by which annexins confer chemoresistance have not been identified, but may be due to inhibition of apoptosis. Annexin-A1 has been shown to enhance apoptosis, whilst annexin-A2, by contrast, inhibits apoptosis. © 2008 Elsevier Ltd. All rights reserved.