Publication: Platelet inhibitory effects of juices from Pachyrhizus erosus L. root and Psidium guajava L. fruit: a randomized controlled trial in healthy volunteers
1
Issued Date
2016
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eng
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Mahidol University
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BioMed Central
Bibliographic Citation
BMC Complementary and Alternative Medicine. Vol. 16, (2016), 269
Suggested Citation
Thitiporn Thaptimthong, Thitima Kasemsuk, Nathawut Sibmooh, Supeenun Unchern Platelet inhibitory effects of juices from Pachyrhizus erosus L. root and Psidium guajava L. fruit: a randomized controlled trial in healthy volunteers. BMC Complementary and Alternative Medicine. Vol. 16, (2016), 269. doi:10.1186/s12906-016-1255-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/2742
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Title
Platelet inhibitory effects of juices from Pachyrhizus erosus L. root and Psidium guajava L. fruit: a randomized controlled trial in healthy volunteers
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Abstract
Background: The purpose of this study is to investigate cardiovascular benefits of juices obtained from two
commonly consumed fruits in Thailand, Pachyrhizus erosus, L. (yam bean) and Psidium guajava, L. (guava), by
examining their acute cardiovascular effects in healthy volunteers. Possible involvements of the dietary nitrate on
their effects were investigated as well.
Method: Thirty healthy volunteers were randomly divided into three groups of 10 subjects per group and each
group was allocated to drink 500 ml of freshly prepared yam bean root juice, guava fruit juice, or water. Systemic
nitrate and nitrite concentrations, heart rate, systolic and diastolic blood pressure, serum K+ concentrations, ex vivo
platelet aggregation, and plasma cGMP concentrations were monitored at the baseline and at various time points
after the intake of juices or water. Data were compared by repeated measures ANOVA.
Results: Following the ingestion of both yam bean root juice and guava fruit juice, collagen-induced but not
ADP-induced platelet aggregation was attenuated. Ingestion of yam bean root juice increased systemic nitrate
and nitrite concentrations whereby elevated nitrite concentrations correlated with the extent of inhibiting
collagen-induced platelet aggregation. In addition, positive correlation between systemic nitrite and plasma cGMP
concentrations and negative correlation between plasma cGMP concentrations and the extent of collagen-induced
platelet aggregation were revealed. Nevertheless, yam bean root juice reduced only diastolic blood pressure while
guava fruit juice reduced heart rate, systolic and diastolic blood pressure.
Conclusion: The present study has illustrated, for the first time, acute inhibitory effects of yam bean root juice and
guava fruit juice on ex vivo collagen-induced platelet aggregation in healthy subjects. Dietary nitrate was shown
to underlie the effect of yam bean root juice but not that of guava fruit juice. Following yam bean root juice
ingestion, systemic nitrate apparently converts to nitrite and further to NO which may attenuate platelet responses
to collagen stimulation. Cardiovascular benefits of juices from yam bean root and guava fruit are noteworthy in
term of the cardiovascular health-promoting approach.
Trial registration: Randomized controlled trial TCTR20150228001.