Publication: Anti-necrosis potential of polyphenols against snake venoms
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Issued Date
2009-12-01
Resource Type
ISSN
15322513
08923973
08923973
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2-s2.0-67651141749
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Mahidol University
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SCOPUS
Bibliographic Citation
Immunopharmacology and Immunotoxicology. Vol.31, No.4 (2009), 556-562
Suggested Citation
Jiraporn Leanpolchareanchai, Pimolpan Pithayanukul, Rapepol Bavovada Anti-necrosis potential of polyphenols against snake venoms. Immunopharmacology and Immunotoxicology. Vol.31, No.4 (2009), 556-562. doi:10.3109/08923970902821702 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27616
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Title
Anti-necrosis potential of polyphenols against snake venoms
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Abstract
Polyphenols from the extracts of Areca catechu L. and Quercus infectoria Oliv. inhibited phospholipase A2, proteases, hyaluronidase and L-amino acid oxidase of Naja naja kaouthia Lesson (NK) and Calloselasma rhodostoma Kuhl (CR) venoms by in vitro tests. Both extracts inhibited the hemorrhagic activity of CR venom and the dermonecrotic activity of NK venom by in vivo tests. The inhibitory activity of plant polyphenols against local tissue necrosis induced by snake venoms may be caused by inhibition of inflammatory reactions, hemorrhage, and necrosis. The result implies the therapeutic potential of plant polyphenols against necrosis in snakebite victims. © 2009 Informa UK Ltd.