Publication: Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails
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Issued Date
2009-11-01
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ISSN
10902449
00144894
00144894
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2-s2.0-69449093922
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Mahidol University
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SCOPUS
Bibliographic Citation
Experimental Parasitology. Vol.123, No.3 (2009), 203-211
Suggested Citation
Wannaporn Ittiprasert, Rahul Nene, André Miller, Nithya Raghavan, Fred Lewis, Jacob Hodgson, Matty Knight Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails. Experimental Parasitology. Vol.123, No.3 (2009), 203-211. doi:10.1016/j.exppara.2009.07.015 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27636
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Title
Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails
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Abstract
Schistosomes develop successfully in susceptible snails but are encapsulated and killed in resistant ones. Mechanism(s) shaping these outcomes involves the parasites ability to evade the snail's defenses. RNA analysis from resistant (BS-90), non-susceptible (LAC2) and susceptible (NMRI) juvenile Biomphalaria glabrata to Schistosoma mansoni revealed that stress-related genes, heat shock protein 70 (Hsp 70) and reverse transcriptase (RT), were dramatically co-induced early in susceptible snails, but not in resistant/non-susceptible ones. These transcripts were, however, down regulated upon exposure to irradiated parasites although penetration behavior of irradiated vs. normal parasites were the same, indicating that Hsp 70 and RT regulation was elicited by infection and not injury. Understanding molecular events involved in stress response transcriptional regulation of Hsp 70 in juvenile snails could pave a way towards the identification of genes involved in schistosome/snail interactions. © 2009 Elsevier Inc. All rights reserved.