Publication: Patterns of managing chronic hepatitis B treatment-related drug resistance: A survey of physicians in Mainland China, South Korea, Taiwan, and Thailand
2
Issued Date
2009-06-24
Resource Type
ISSN
19360541
19360533
19360533
Other identifier(s)
2-s2.0-68949158471
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Mahidol University
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SCOPUS
Bibliographic Citation
Hepatology International. Vol.3, No.3 (2009), 453-460
Suggested Citation
Siwaporn Chainuvati, Jun Cheng, Jin Lin Hou, Chao Wei Hsu, Ji Dong Jia, Piyawat Komolmit, So Young Kwon, Chang Hong Lee, Hong Li, Ying Li, Chun Jen Liu, Boon Leong Neo, Cheng Yuan Peng, Tawesak Tanwandee, Suchat Wongcharatrawee, Jaw Ching Wu, Ming Lung Yu, Xin Xin Zhang Patterns of managing chronic hepatitis B treatment-related drug resistance: A survey of physicians in Mainland China, South Korea, Taiwan, and Thailand. Hepatology International. Vol.3, No.3 (2009), 453-460. doi:10.1007/s12072-009-9139-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28044
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Title
Patterns of managing chronic hepatitis B treatment-related drug resistance: A survey of physicians in Mainland China, South Korea, Taiwan, and Thailand
Other Contributor(s)
Mahidol University
Beijing Ditan Hospital
Southern Medical University
Chang Gung University College of Medicine
Capital Medical University China
Chulalongkorn University
Konkuk University, College of Medicine
Bristol-Myers Squibb
National Taiwan University
China Medical University Hospital Taichung
National Yang-Ming University, School of Medicine
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung Medical University
Ruijin Hospital
Beijing Ditan Hospital
Southern Medical University
Chang Gung University College of Medicine
Capital Medical University China
Chulalongkorn University
Konkuk University, College of Medicine
Bristol-Myers Squibb
National Taiwan University
China Medical University Hospital Taichung
National Yang-Ming University, School of Medicine
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung Medical University
Ruijin Hospital
Abstract
Purpose: The emergence of antiviral resistance can negate the benefits of antiviral therapy in patients with chronic hepatitis B (CHB). This study aimed to assess how physicians in Asia manage suspected antiviral resistance. Methods: Randomly selected CHB-treating physicians in Mainland China, South Korea, Taiwan, and Thailand underwent a face-to-face interview. A standardized questionnaire was used to assess how physicians identify, monitor, and manage suspected resistance and its associated medical costs. Results: We interviewed 575 physicians from January to May 2008. Most physicians preferred a "prevention-of-antiviral resistance" strategy over a "rescue-once-resistance-develops" strategy. Physicians had encountered lamivudine resistance most frequently (96 - 100% of respondents), followed by the resistance to adefovir (18 - 58%) and entecavir (3 - 7%). While physicians in South Korea and Taiwan have access to resistance testing, physicians in Mainland China and Thailand have limited access to resistance testing but rely on HBV DNA and alanine aminotransferase (ALT) tests to identify resistance. Once resistance is suspected, 60% of the physicians in Mainland China, South Korea, and Thailand monitored these patients quarterly and the remaining 40% opted for monthly follow-up. In comparison, 70% of the Taiwanese physicians monitored these patients monthly. The average total direct medical costs, excluding antiviral costs, to manage a patient during the first year after suspected resistance is identified ranged from USD $319 to USD $709. Conclusions: Limited access to HBV resistance tests causes physicians in Asia to manage suspected resistance by various HBV DNA assays and ALT tests. This raises concerns that resistance may not be detected early enough to be rescued efficiently. © Asian Pacific Association for the Study of the Liver 2009.